аЯрЁБс;ўџ ўџџџўџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџ§џџџўџџџ  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopўџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџRџџџџџџџџ€bШxыМўџџџPageMakerџџџџџџџџџџџџмџџџџџџџџџџџџџџџџџџџџџџџџ™џ€  Mыˆк@к@3 и@џџ€ и@№Р#gcЋРPM2MлШЯ аЯ ˆ мIED="866570810">Excite Search - U.K. Editi аhLаи аkZа4™&@@аPє}P@аPPdPЄ0 P@а`Р`@аLPаєP&P^UаNPв& Р@&в4P ’аа$о7аMSP B@@P&а> а;ŽаG@3L@d@№а2@6PkZа3LP№аЂ1 @@аа њ>P `@аќ а@}а.­+@@а>The Road to Eleusis - Contents
;^>^=.^>ёP,  ёNicholas HD:PM6.5 Help ёNicholas HD:xA7799ddшу‹еьuњwу‹‰u*№№№№№№  dМяш№bј Єpп№ ..--__(b|@џџ >еьњw‰*у‹еьuњwу‹‰u*џџџџџџџџ€!€@eР к@€$џџGeneva$џџр(xK–dџћЈdџџdџџxџџџџМGMMdBody textџџџџџџџџџџџџџџџџџџџџџџ(xK–dџћЈdџџdџџdџџџџМGMMdCaptionџџџџџџџџџџџџџџџџџџџџџџ№№џ(xK–dџћЈdџџdџџxџџџџМGMMdHanging indentџџџџџџџџџџџџџџџџџџџџџџU(xK–dџћЈdџџdџџ,џџџџМGMMdHeadlineџџџџџџџџџџџџџџџџџџџџџџU(xK–dџћЈdџџdџџДџџџџМGMMdSubhead 1џџџџџџџџџџџџџџџџџџU(xK–dџћЈdџџdџџxџџџџМGMMdSubhead 2џџџџџџџџџџџџџџџџџџNone џџџџџџџџџџџџџџџџџџRegistrationџџџџџџџџџџџџџџџџџџџџџџџџPaper џџџџџџџџџџџџџџџџџџBlackPџџџџџџRed џџџџџџџџџџџџџџGreen џџџџџџџџџџџџџџBlue џџџџџџџџџџџџџџCyanPџџџџџџр YЦˆр YЦˆMagentaPџџџџџџјx€ајx€аYellowPџџџџџџџџўКџџўКdЈDллллAdobe Compatibility CMSAdobe Compatibility CMSPageMaker 5.0 RGBDллллAdobe Compatibility CMS Adobe Compatibility CMSPageMaker 5.0 CMYKDefault€Document Masterеьњw‰*у‹еьuњwу‹‰u*Document Masterеьњw‰*у‹еьuњwу‹‰u*Reductions of 5-HT Transporters in MDMA Users Observed Using PET With IC-11(+)McN5652. Z. Szabo, U. Scheffel, U.McCann, R.F. Dannals, H.T. Ravert, W.B. Mathews, J.L. Musachio, G.Ricaurte Department of Radiology and Neurology The John Hopkins University, Baltimore, MD 21205 The recreational drug, 3,4-methylenedioxymethamphetamine (MDMA), produces long-lasting deficits of serotonin axonal markers in animals, including primates. It is not known whether humans are also susceptible to MDMA-induced serotonin injury. In the present study, [C-1](+)McN5652, a PET neuroligand selective for the serotonin transporter (5-HT), was used to assess the status of serotonin axonal terminals in MDMA users. Fourteen MDMA users (27Б10y) who had not used MDMA for greater than three weeks and eight MDMA-naive controls (38Б19y) were injected with 18Б1 mCi high specific activity |C-11)(+)McN5652. Sequential PET scans were acquired over 95 minutes and regional time-activity curves were processed using metabolite corrected arterial plasma activity as the input function. Compartmental parameters of radioligand uptake (K1), release (k2) and distribution volume (DV=K1/K2) were obtained by the Marquarddt algorithm. In order to achieve normal (Gau?sian) distribution, the natural logarithm InDV was used as a measure of radioligand binding. Logarithmic transformation across all regions and subjects resulted in a pooled coefficient variation of 32%. MDMA subjects had a clear reduction of mean InDV in all brain regions compared to controls (MANOVA F=4.64: p=0.02). The covariance effect of age was insignificant (F=2.43; p=0.1). These results provide the first PET evidence of reduced 5-HT in individuals with past history of MDMA use and suggest that humans are susceptible to MDMA-induced serotonin neurotoxicity. This work was supported by grants DA 10217 and DA 06275ExџџџџМGMMdEџџџџ(xK–dџћЈdџџdџџEРџџ€ €џџ€€џџ€Рџџ€џџ€%џџ€%џџ€€џџ€ €џџ€0џџ€0џџ€* Рџџ€*(џџ€(џџ€.@!€џџ€.1a€џџ€1џџ€/aРџџ€/џџ€џџ€џџ€џџ€ џџ€ EeРџџ€ m@џџ€ m€џџ€ nџџ€ TimesЄџџGenevaЄџџAGaramond BoldItalic8ъ€џџAGaramond Bold8ы€џџAGaramond SemiboldItalic8р€џџAGaramond Italic8у€џџAGaramond Semibold8с€џџAGaramond8т€џџWoodtype Ornaments 13/€џџAvant Garde!€џџBookman€џџCalligraphys€џџI Cooper Black Italic:4€џџCooper Black:3€џџCourier€џџDelphianз€џџGaramond Narrowа€џџHelvetica€џџHelvetica Black:~€џџHelvetica Compressed9л€џџGaramond BoldCondensed"х€џџGaramond BoldCondensedItalic"ф€џџGaramond BookCondensed"ч€џџGaramond BookCondensedItalic"ц€џџGaramond LightCondensed"щ€џџGaramond LightCondensedItalic"ш€џџGaramond UltraCondensed"у€џџGaramond UltraCondensedItalic"т€џџITC Officina Sans BoldItalicn€џџITC Officina Sans BookItalicl€џџITC Officina Sans Boldm€џџITC Officina Sans Bookk€џџITC Officina Serif BoldItalicj€џџITC Officina Serif BookItalich€џџITC Officina Serif Boldi€џџITC Officina Serif Bookg€џџKlang MT*X€џџLubalin Graphс€џџLucida Bright€џџMachineш€џџMS LineDrawў€џџN Helvetica Narrow€џџNadianneэ€џџNew Century Schlbk"€џџNew York€џџNuptialScript3Ё€џџOld English Textє€џџOnyxі€џџOxfordј€џџPalatino€џџSwingў€џџSymbol€џџBlk VAG Rounded Black9€џџL VAG Rounded Light9€џџB VAG Rounded Bold9€џџT VAG Rounded Thin9€џџZapf Chancery€џџZapf Dingbats €џџZeal€џџMonaco€џџChicago€џџs
ЈDллллAdobe Compatibility CMSAdobe Compatibility CMSPageMaker 5.0 RGBDллллAdobe Compatibility CMS Adobe Compatibility CMSPageMaker 5.0 CMYKsxџџџџМGMMd"http://www.lycaeum.org/drugs/plansџџџџ(xK–dџћЈdџџdџџth the risk, if you pick or grow shrooms it's easPsilocybin is juuust fine. IРџџ€ €џџ€€џџ€=pРџџ€џџ€%џџ€%џџ€€џџ€ €џџ€0џџ€0џџ€* Рџџ€*(џџ€(џџ€.@–Рџџ€.1a€џџ€1џџ€/aРџџ€/џџ€џџ€џџ€џџ€ џџ€ s‡@џџ€ жРџџ€ зџџ€ з€џџ€ your head; Starring You and Your Brain for 12 hours. Every perception magnified thousandfold -- it's ... it's a bit too intense. !INTENSE! is the keyword. It doesn't accept any apologies or mistakes ... too harsh. I often felt like I had been immersed in some chemical, into a substance so pure and efficient it has no place in nature. Too pure. 12 hours of LSD-25 acid-bath makes you really tired... physically and mentally. But psilocybin, mm-mm, it's juuuuust fiiiine.

Voyage to the spiritworld ... visions and travels, awesome mental hallucinations. It's a direct ISDN-link to the mother earth, forgiving, gentle substance. You hear the chanting of the planet and the spirit of the mushroom. It's a product of the nature, untied to the actions of men and women roaming this planet. Your body disconnected from the circuit, you may often forget it exists. Six hours